Apigenin: The Anxiolytic Constituent of Turnera aphrodisiaca
نویسندگان
چکیده
Turnera aphrodisiacaWard (Turneraceae) has been traditionally used for the treatment of anxiety neurosis and as aphrodisiac, but no attempts have been made to investigate the plant systematically for its traditional claims. The current investigation was carried out ot isolate the bioactive constituent(s) from T. aphrodisiaca using bioactivity-guided fractionation. Antianxiety activityguided fractionation of methanol extract of the plant led to isolation of 5,7,40 -trihydroxy flavone apigenin. Its structure was elucidated by UV and NMR data. Apigenin exhibited significant anxiolytic activity at a dose of 2mg=kg, p.o., in mice using elevated plus maze model of anxiety. It is concluded that apigenin is responsible for anxiolytic effects of this traditionally used plant.
منابع مشابه
Estimation of Apigenin, an Anxiolytic Constituent, in Turnera aphrodisiaca
An HPTLC densitometric method has been developed to estimate apigenin in Turnera aphrodisiaca aerial and its segregated parts (leaves, stems, flowers and fruits) so that plant can be standardized on the basis of its bioactive marker. The apigenin content in methanol extract of T. aphrodisiaca aerial parts was found to be about fourteen times less than acid hydrolyzed methanol extract of the pla...
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